Unnatural evolutionary processes of SARS-CoV-2 variants
info
2023-08-28
1 - Omicron variants were already present in 2020
2 - Omicron isolates BA.1, BA.1.1, and BA.2 were not the product of 26 genome evolution, as is commonly observed in nature
This https://zenodo.org/record/8254894 preprint states:
Abstract 17 Over the past three years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has repeatedly 18 caused pandemics, generating various mutated variants ranging from Alpha to Omicron. In this study, we 19 aimed to clarify the evolutionary processes leading to the formation of SARS-CoV-2 Omicron variants, 20 focusing on Omicron variants with many amino acid mutations in the spike protein among SARS-CoV-2 21 isolates. To determine the order of mutations leading to the formation of the SARS-CoV-2 Omicron variants, 22 we compared the sequences of 129 Omicron BA.1-related, 141 BA.1.1-related, and 122 BA.2-related isolates, 23 and attempted to clarify the evolutionary processes of SARS-CoV-2 Omicron variants, including the order of 24 mutations leading to their formation and the occurrence of homologous recombination.
As a result, we 25 concluded that the formation of a part of Omicron isolates BA.1, BA.1.1, and BA.2 was not the product of genome evolution, as is commonly observed in nature, such as the accumulation of mutations and homologous 27 recombinations. Furthermore, the study of 35 recombinant isolates of Omicron variants BA.1 and BA.2 28 confirmed that Omicron variants were already present in 2020. The analysis showed that Omicron variants 29 were formed by an entirely new mechanism that cannot be explained by previous biology, and knowing how 30 the SARS-CoV-2 variants were formed prompts a reconsideration of the SARS-CoV-2 pandemic.
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Consider that the SARS-CoV-2 Omicron variant and its one-amino-acid reversion mutants were artificially and 257 systematically generated. In that case, we should suspect that the other variants (Alpha to Delta) were also 258 artificially generated viruses.
How convenient to be prepared for the next variant:
